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Medchemexpress LLC Sacubitril sodium | 149690-05-1 | C24H28NNaO5 | 1 ML
Supplier: Medchemexpress LLC HY15407B10MM/1ML
Sacubitril sodium is a potent and orally active neprilysin (NEP) inhibitor, with an IC50 of 5 nM. It enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. It is a component of the heart failure medicine LCZ696 and can be used for the research of heart failure, hypertension, and COVID-19.
- Increases neprilysin-degraded peptides (NPs, ANP, BNP)
- Augments ANP-evoked plasma cGMP levels in normotensive rats
- Produces a dose-dependent antihypertensive effect in Dahl-SS rats
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