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Medchemexpress LLC SAG (hydrochloride) | 2095432-58-7 | 99.91% | 1 MG
SDP

Catalog No. 5000339164
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SAG hydrochloride is a potent Smoothened (Smo) receptor agonist with an EC50 of 3 nM and a Kd of 59 nM. It activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.

  • Induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.
  • Competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, showing a dissociation constant (Kd) of 59 nM.
  • Increases SMO mRNA and protein expression in MDAMB231 cells.
  • Increases CAXII mRNA expression in MDAMB231 cells under normoxic and hypoxic conditions.
  • Increases MDAMB231 cell migration.
  • Promotes osteogenesis and significantly increases BV/TV in CD-1 mice.
  • Induces pre-axial polydactyly and increases Gli1 and Gli2 mRNA expression in the limb bud in mice.

Catalog No. 50-003-39164 Supplier Medchemexpress LLC Supplier No. HY12848B1MG
May include imposed supplier surcharges.
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SAG hydrochloride is a potent Smoothened (Smo) receptor agonist with an EC50 of 3 nM and a Kd of 59 nM. It activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.

  • Induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.
  • Competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, showing a dissociation constant (Kd) of 59 nM.
  • Increases SMO mRNA and protein expression in MDAMB231 cells.
  • Increases CAXII mRNA expression in MDAMB231 cells under normoxic and hypoxic conditions.
  • Increases MDAMB231 cell migration.
  • Promotes osteogenesis and significantly increases BV/TV in CD-1 mice.
  • Induces pre-axial polydactyly and increases Gli1 and Gli2 mRNA expression in the limb bud in mice.

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