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Tocris™ SAH-SOS1A

Catalog No. 6920500U
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500 μg
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Catalog No. Quantity
69-205-00U 500 μg
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Catalog No. 69-205-00U Supplier Tocris™ Supplier No. 6920/500U

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

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Description

KRas/SOS1 interaction inhibitor

SAH-SOS1A is a KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

Sold under license from Dana-Farber Cancer Institute

Specifications

CAS 1652561-87-9
Content And Storage Store at -20°C
Description KRas/SOS1 interaction inhibitor
Formulation C100H159N27O28
Molecular Weight (g/mol) 2187.53
Quantity 500 μg
Sequence RRFFGIXLTNXLKTEEGN (Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-7 and X-11 stapled together with a double bond)
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