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Apexbio Technology LLC Sal 003 1164470-53-4 10mg
Supplier: Apexbio Technology LLC A454110
Sal 003 (CAS 1164470-53-4) is a selective inhibitor of eukaryotic initiation factor 2 (eIF2 ) dephosphorylation By blocking eIF2 phosphatase activity Sal 003 impedes the removal of phosphate groups from eIF2 thereby modulating protein synthesis In vitro treatment with Sal 003 results in polysome dissociation and a shift of -actin mRNA towards lighter polysome fractions indicating translational repression In vivo intra-amygdala administration following memory retrieval disrupts reconsolidation of drug-associated memories and decreases reinstatement of drug-seeking behaviors in animal models Sal 003 is thus valuable for investigating the regulation of protein translation and memory reconsolidation
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