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Medchemexpress LLC Salicylic acid | 69-72-7 | 98.4% | 50 G
Supplier: Medchemexpress LLC HYB016750G
Salicylic acid (2-Hydroxybenzoic acid) is an inhibitor of cyclo-oxygenase-2 (COX-2) activity that works independently of transcription factor (NF-κB) activation. It also possesses blood-brain barrier permeability. It inhibits prostaglandin E2 release with an IC50 of 5 μg/mL and acutely causes a concentration-dependent inhibition of COX-2 activity.
- Inhibits prostaglandin E2 release with an IC50 of 5 μg/mL
- Acutely causes a concentration-dependent inhibition of COX-2 activity
- Reduces both fasting and postprandial plasma glucose levels
- Shows a trend to reduce plasma triglyceride levels
- Significantly reduces 11β-HSD1 mRNA in omental adipose tissue
- Reduces 11β-HSD1 enzyme activity in mesenteric adipose
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