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Apexbio Technology LLC Salinomycin 53003-10-4 10mg
Supplier: Apexbio Technology LLC A378510
Salinomycin is a polyether ionophore antibiotic derived from Streptomyces albus with demonstrated antitumor activities against various cancer cell types It is proposed to function by disrupting multiple signaling pathways including Wnt/ -catenin signaling and interference with ABC drug transport proteins In vitro research on human hepatocellular carcinoma (HCC) cell lines HepG2 SMMC-7721 and BEL-7402 indicates antiproliferative effects with IC50 values of 7 7 M 13 7 M and 10 4 M respectively after 24-hour treatment Studies show that salinomycin induces cell cycle arrest apoptosis via increased Bax/Bcl-2 ratio reduces -catenin expression and elevates intracellular calcium concentrations In vivo assays using orthotopic liver cancer models corroborate its antiproliferative and pro-apoptotic activities suggesting utility in oncology research
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