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Apexbio Technology LLC SANT-1 304909-07-7 10mg
Supplier: Apexbio Technology LLC A865910
SANT-1 (CAS 304909-07-7) is a small molecule antagonist targeting the Smoothened (Smo) transmembrane protein a central component of the Hedgehog (Hh) signaling pathway Dysregulation of Smo activity is implicated in aberrant cell differentiation and proliferation contributing to oncogenesis High-throughput assays indicate that SANT-1 exhibits potent inhibition of Smo with IC50 values of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 cell models respectively and demonstrates high binding affinity (KD 1 2 nM) In pancreatic cancer cell lines SANT-1 suppresses Panc-1 cell growth with an IC50 of 100 M Additionally co-administration with SAHA enhances anti-tumor effects via synergistic inhibition of Hh signaling SANT-1 serves as a valuable research tool for studying Hh pathway modulation and investigating combination therapeutic strategies in cancer models
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