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Medchemexpress LLC Saroglitazar magnesium | 1639792-20-3 | 98.85% | 901.42 | 25 MG
Supplier: Medchemexpress LLC 25MGHY19937A
Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist that exhibits predominant PPARα activity and moderate PPARγ activity, with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.
- Novel peroxisome proliferator-activated receptor (PPAR) agonist
- Predominant PPARα activity (EC50 of 0.65 pM in HepG2 cells)
- Moderate PPARγ activity (EC50 of 3 nM in HepG2 cells)
- Causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose in db/db mice
- Shows lipid-lowering effects in preclinical models
- Indicated low risk of PPAR-associated side effects in humans
- Appears to have good potential as a novel therapeutic agent for the treatment of dyslipidemia and diabetes
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