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Cayman Chemical SaroglItazar MagnsIum 10mg
Supplier: Cayman Chemical 4169410 MG
A PPARα and PPARγ dual agonist (EC50s = 0.65 and 3,000 pM, respectively); decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes at 0.01-3 mg/kg; increases insulin sensitivity in an oral glucose challenge at 1 mg/kg; reverses palmitic acid-induced decreases in the expression of mRNA encoding SOD1, SOD2, GPX, and catalase and increases in the expression of mRNA encoding TNF-α, IL-1β, and IL-6 in HepG2 cells at 10 µM; decreases hepatic inflammation and steatosis in a mouse model of NASH induced by a choline-deficient high-fat diet at 3 mg/kg
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