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Cayman Chemical SARS-CoV-2 nsp8recombInt 100ug
SDP

Supplier:  Cayman Chemical 40882100 UG

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A mitochondrial complex I inhibitor selective for complex I inhibiting it by 77.6 over complex III which it inhibits by 28.1 and complexes II and IV which it does not inhibit at 1 UM selectively reduces viability of H460 NCI H441 and trametinib-resistant A549 cells (IC50s 10.6 29.7 and 15.1 nM respectively) which all display high levels of oxidative phosphorylation over NCI H358 cells (IC50 10000 nM) which display low levels of oxidative phosphorylation and non-cancerous HPNE and MRC-5 cells (IC50s 10000 nM for both) reduces tumor volume in an H460 mouse xenograft model at 30 mg/kg twice per day has an additive effect on trametinib-induced tumor growth reduction

Catalog No. 50-294-5021


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