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Cayman Chemical SARS-CoV-2 nutralIzng ntIb 1ea
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Supplier:  Cayman Chemical 5022011 EA

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An ALK4 and ALK5 inhibitor (IC50s 113 and 343 nM respectively) selective for ALK4 and ALK5 over a panel of 467 kinases at 1 UM inhibits ALK4 or ALK5 signaling in a reporter assay using HEK293 cells expressing ALK4 or ALK5 (IC50s 526 and 245 nM respectively) inhibits TGF-B1-induced increases in the levels of phosphorylated Smad2 in C2C12 myoblasts at 1 or 10 UM induces valvular interstitial cell proliferation neutrophil infiltration hemorrhage and fibrin deposition in rat heart valves at 150 or 500 mg/kg per day

Catalog No. 50-289-5221


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