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AdipoGen SARS-CoV-2 Spike Protein S1 (RBD) (rec.) (GST-His) (100 µg)
Supplier: AdipoGen CHIB249001C100
Recombinant Proteins. Receptor-binding domain (RBD) of SARS-CoV-2 Spike protein S1 (aa 330-530) is fused at the N-terminus to a GST-tag and at the C-terminus to a His-tag. Source: HEK 293 cells. Lyophilized. Contains PBS. Endotoxin levels: <0.001EU/µg purified protein (LAL test). The CoV Spike (S) protein assembles as trimer and plays the most important role in viral attachment, fusion and entry. It is composed of a short intracellular tail, a transmembrane anchor and a large ectodomain that consists of a receptor binding S1 subunit (RBD domain) and a membrane-fusing S2 subunit. However, analysis of the receptor binding motif (RBM) in the S protein showed that most of the amino acid residues essential for receptor binding were conserved between SARS-CoV and SARS-CoV-2, suggesting that the 2 CoV strains use the same host receptor for cell entry, the receptor angiotensin-converting enzyme 2 (ACE2).
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