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ACROBiosystems SARS-CoV-2 Spike protein 500ug

Supplier:  ACROBiosystems SPNC524U500UG

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SARS-CoV-2 Spike Trimer Protein His Tag (EG.5/Omicron) (SPN-C524u) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1 (T19I LPP24-26del A27S V83A G142D Y144del H146Q Q183E V213E G252V G339H R346T L368I S371F S373P S375F T376A D405N R408S K417N N440K V445P G446S F456L N460K S477N T478K E484A F486P F490S Q498R N501Y Y505H D614G H655Y N679K P681H N764K D796Y Q954H N969K R683A R685A F817P A892P A899P A942P K986P V987P)). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: EG.5). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P A892P A899P A942P K986P V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site respectively.

Catalog No. 50-253-4130


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