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ACROBiosystems ACROBiosystems SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)

Supplier:  ACROBiosystems SPNC52HE50UG

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Recombinant Protein;50UG;SARS-CoV-2 Spike Trimer, His Tag (SPN-C52He) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The mutations (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N) were identified in the SARS-CoV-2 variants which emerged in India (known as B.1.617.2). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the N-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.;This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 137.8 kDa. The protein migrates as 140-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.;Immobilized SARS-CoV-2 Spike Trimer, His Tag (Cat. No. SPN-C52H

Catalog No. 50-210-6995


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