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Cayman Chemical SARSCoV2 nsp16 Methyltrnsf

Supplier: Cayman Chemical 31816100 UG

An orally bioavailable ACE and NEP inhibitor (IC50s 1.7 and 5.3 nM respectively for the human enzymes) inhibits the angiotensin I-induced pressor response in normotensive rats (ED50 0.07 Umol/kg) lowers MAP in sodium-depleted spontaneously hypertensive rats at 30 Umol/kg lowers MAP in rats when co-administered with bradykinin increases tracheal plasma extravasation in a rat model of upper airway angioedema in a dose-dependent manner
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