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Apexbio Technology LLC SB 203580 152121-47-6 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A82545.1

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SB 203580 (CAS 152121-47-6) is a pyridinyl imidazole derivative acting as a selective inhibitor of the p38 mitogen-activated protein kinase (MAPK) It competes with ATP binding at or near the kinase ATP-binding region showing a Ki of 21 nM SB 203580 is also reported to inhibit c-Raf in vitro (IC50 2 mM) Experimental studies indicate that SB 203580 reverses multidrug resistance in L1210/VCR cells by reducing tolerance to vincristine Additionally the compound is instrumental in investigating the p38 MAPK pathway in cellular signaling and ischemic neuroprotection models

Catalog No. 50-000-62028


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