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Apexbio Technology LLC SB 203580 hydrochloride 869185-85-3 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC B12855.1

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SB 203580 hydrochloride (CAS 869185-85-3) is a selective inhibitor targeting the p38 mitogen-activated protein kinases (MAPKs) specifically isoforms p38-MAPK and p38-MAPK It prevents the downstream phosphorylation and activation of MAP kinase-activated protein kinase 2 (MAPKAPK2) exhibiting an IC50 around 70 nM in neonatal myocytes Additionally SB 203580 hydrochloride inhibits MAPKAPK2 activation and heat shock protein 27 (HSP27) phosphorylation induced by IL-1 osmotic stress or arsenite in KB cells with IC50 values below 1 M It also reduces JNK-mediated activation of c-Jun in neonatal rat cardiac myocytes This compound is widely utilized in research into cellular stress responses inflammation pathways and cardiac signal transduction

Catalog No. 50-000-63235


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