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Apexbio Technology LLC SB 225002 182498-32-4 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC B82005.1

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SB 225002 (CAS 182498-32-4) is a selective non-peptide antagonist targeting the chemokine receptor CXCR2 a G protein-coupled receptor involved in interleukin-8 (IL-8)-mediated neutrophil chemotaxis and polarization It inhibits IL-8 binding to CXCR2 with an IC50 of 22 nM and displays over 150-fold selectivity against CXCR1 SB 225002 suppresses neutrophil migration and polarization triggered by IL-8 and GRO in cell-based assays and animal models It also promotes apoptosis and mitotic catastrophe in ovarian cancer cells independently of p53 status highlighting its utility in inflammation and oncology research

Catalog No. 50-000-64232


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