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Medchemexpress LLC SB-265610 | 211096-49-0 | 98.98% | C14H9BrN6O | 50 MG
Supplier: Medchemexpress LLC HY5068850MG
SB-265610 is a selective, competitive, nonpeptide, and allosteric CXCR2 antagonist. It blocks rat CINC-1-induced calcium mobilization (IC50 of 3.7 nM) and neutrophil chemotaxis (IC50 of 70 nM). In animal models, it significantly inhibits Gr-1+CD11b+ cell recruitment to mammary adenocarcinoma.
- Selective, competitive, nonpeptide, and allosteric CXCR2 antagonist.
- Blocks rat CINC-1-induced calcium mobilization (IC50 of 3.7 nM).
- Blocks neutrophil chemotaxis (IC50 of 70 nM).
- Reduces CINC-1's antiapoptotic effect.
- Inhibits Gr-1+CD11b+ cell recruitment to mammary adenocarcinoma in animal models.
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