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Cayman Chemical SB-271046hydrochlorIde 50mg
SDP

Supplier:  Cayman Chemical 1851350 MG

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PGF2a methyl ester is an analog of PGF2a in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2a methyl ester was one of the first PG esters shown to have ocular hypotensive activity.{8837} This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid PGF2a. This difference is attributed to improved corneal penetration and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 Ug dose of PGF2a-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.{8837}

Catalog No. 50-296-8026


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