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Medchemexpress LLC SB-277011 hydrochloride | 215804-67-4 | 99.59% | 475.02 | 50 MG
Supplier: Medchemexpress LLC HY10847B10MM/1ML
SB-277011 hydrochloride is a potent and selective dopamine D3 receptor (D3R) antagonist, demonstrating high oral bioavailability and brain penetrance. It exhibits significant selectivity over other dopamine receptors and possesses an excellent pharmacokinetic profile in rats. This compound has been shown to effectively reverse the effects of quinelorane and reduce cocaine self-administration in preclinical studies.
- Potent and selective D3 receptor antagonist
- High oral bioavailability and brain penetrance
- 80- to 100-fold selectivity over other dopamine receptors
- Excellent pharmacokinetic profile
- Reverses quinelorane effects in nucleus accumbens
- Reduces intravenous cocaine self-administration
- Inhibits basal and cocaine-enhanced locomotion
- Appearance: solid, off-white to light yellow
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