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Cayman Chemical SB-399885hydrochlorIde 50mg
Supplier: Cayman Chemical 3281750 MG
A 5-HT6 receptor antagonist (Ki = 0.72 nM); >200-fold selective for 5-HT6 receptors over a panel of receptors, ion channels, and enzymes at 10 µM; inhibits 5-HT-induced cAMP accumulation in HeLa cells expressing recombinant human 5-HT6 receptors (pA2 = 7.85); increases the seizure threshold in a rat model of MES-induced seizures; reduces escape latency in the Morris water maze in aged rats and reverses scopolamine-induced impairments in the novel object recognition task in adult rats at 10 mg/kg; has antidepressant and anxiolytic-like effects in mice and rats, respectively
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