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Cayman Chemical SB-399885hydrochlorIde 50mg

Supplier: Cayman Chemical 3281750 MG

A TRPV1 antagonist (Ki 72 nM for the recombinant guinea pig channel) inhibits capsaicin- or pH decrease-induced guinea pig TRPV1 channel activation (IC50s 58 and 470 nM respectively) reduces the number of citric acid- or capsaicin-induced coughs in guinea pigs at 20 mg/kg reduces spontaneous and palpitation-induced flinching and guarding in a mouse model of bone cancer pain at 30 mg/kg decreases capsaicin-induced production of CGRP and inflammatory soup-induced trigeminal expression of cfos in rat models of migraine
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