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Medchemexpress LLC SB-408124 Hydrochloride | 1431697-90-3 | 98.8% | C19H19ClF2N4O | 100 MG
Supplier: Medchemexpress LLC HY76612100MG
SB-408124 Hydrochloride is a selective, non-peptide orexin receptor 1 (OX1) antagonist. It demonstrates high potency with Ki values of 57 nM in whole cells and 27 nM in membranes, exhibiting 50-fold selectivity over the OX2 receptor. This compound is for research use only.
- Potent OX1 receptor antagonist (Ki: 57 nM in whole cells, 27 nM in membranes)
- Exhibits 50-fold selectivity over OX2 receptor
- Attenuates orexin A-induced AVP mRNA levels in neuronal cultures
- Reduces anxiety and restores corticoliberin levels in vivo
- Demonstrates an anxiolytic effect
- Reduces mean arterial pressure in salt-sensitive rats
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