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Medchemexpress LLC SB 452533 | 459429-39-1 | 99.11% | 376.29 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY108458100MG

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SB 452533 is a potent and selective TRPV1 antagonist with a pKb of 7.8. It functions by acting as a potent antagonist at the cloned recombinant rat TRPV1 receptor in HEK293 cells. This compound has been shown to reduce phosphorylation of CAMKK2 and AMPK, and to abolish the effects of Capsaicin in reducing Bleomycin-induced pulmonary fibrosis in mice.

  • Potent and selective TRPV1 antagonist
  • Reduces phosphorylation of CAMKK2 and AMPK
  • Abolishes the effects of capsaicin in reducing bleomycin-induced pulmonary fibrosis in mice

Catalog No. 50-003-46540


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