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Medchemexpress LLC SB-590885 | 405554-55-4 | 99.8% | 453.54 | 50 MG
SDP

Catalog No. 5000345132
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SB-590885 is a potent B-Raf inhibitor that exhibits high selectivity for B-Raf over c-Raf and other human kinases. It effectively inhibits ERK phosphorylation and proliferation in various melanoma cell lines expressing oncogenic B-RafV600E. This compound has also been shown to decrease anchorage-independent growth of melanoma cells and reduce tumorigenesis in murine xenografts.

  • Potent B-Raf inhibitor with a Ki of 0.16 nM.
  • Exhibits 11-fold greater selectivity for B-Raf over c-Raf.
  • No inhibition of other human kinases.
  • Stabilizes the oncogenic B-Raf kinase domain in an active configuration.
  • Inhibits ERK phosphorylation and proliferation in B-RafV600E melanoma cells.
  • Decreases anchorage-independent growth of melanoma cell lines.
  • Potently decreases tumorigenesis in murine xenografts.

Catalog No. 50-003-45132 Supplier Medchemexpress LLC Supplier No. HY10966R1MG
May include imposed supplier surcharges.
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SB-590885 is a potent B-Raf inhibitor that exhibits high selectivity for B-Raf over c-Raf and other human kinases. It effectively inhibits ERK phosphorylation and proliferation in various melanoma cell lines expressing oncogenic B-RafV600E. This compound has also been shown to decrease anchorage-independent growth of melanoma cells and reduce tumorigenesis in murine xenografts.

  • Potent B-Raf inhibitor with a Ki of 0.16 nM.
  • Exhibits 11-fold greater selectivity for B-Raf over c-Raf.
  • No inhibition of other human kinases.
  • Stabilizes the oncogenic B-Raf kinase domain in an active configuration.
  • Inhibits ERK phosphorylation and proliferation in B-RafV600E melanoma cells.
  • Decreases anchorage-independent growth of melanoma cell lines.
  • Potently decreases tumorigenesis in murine xenografts.

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