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Medchemexpress LLC SB-616234-A | 908601-49-0 | 99.4% | 574.11 | 1 ML
SDP

Catalog No. 5000384034
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SB-616234-A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.

  • Selective and orally bioavailable 5-HT1B receptor antagonist.
  • Exhibits anxiolytic and antidepressant activity.
  • High affinity for human 5-HT1B receptors (pKi 8.3 ± 0.2).
  • Over 100-fold selectivity for a range of molecular targets, excluding h5-HT1D receptors.
  • Reverses SKF-99101H-induced hypothermia in guinea pigs.
  • Produces dose-related anxiolytic effects in rat and guinea pig maternal separation-induced vocalization models.
  • Causes dose-dependent inhibition of ex vivo [3H]-GR125743 binding to rat striatal 5-HT1B receptors.

Catalog No. 50-003-84034 Supplier Medchemexpress LLC Supplier No. HY1947710MM/1ML
May include imposed supplier surcharges.
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SB-616234-A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.

  • Selective and orally bioavailable 5-HT1B receptor antagonist.
  • Exhibits anxiolytic and antidepressant activity.
  • High affinity for human 5-HT1B receptors (pKi 8.3 ± 0.2).
  • Over 100-fold selectivity for a range of molecular targets, excluding h5-HT1D receptors.
  • Reverses SKF-99101H-induced hypothermia in guinea pigs.
  • Produces dose-related anxiolytic effects in rat and guinea pig maternal separation-induced vocalization models.
  • Causes dose-dependent inhibition of ex vivo [3H]-GR125743 binding to rat striatal 5-HT1B receptors.

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