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Medchemexpress LLC SB-743921 hydrochloride | 940929-33-9 | 99.8% | 553.52 | 10 MG
Supplier: Medchemexpress LLC 10MGHY12069
SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
- Potently inhibits colony-forming cell (CFC) formation of chronic myeloid leukemia (CML) primary cells.
- Exhibits slight inhibitory activities on the colony-forming ability of normal bone marrow progenitors.
- Induces apoptosis of CML primary CD34+ cells, with slight effect on normal CD34+ cells.
- Displays additive anti-proliferative effect in KCL22 and CML CD34+ cells when combined with imatinib.
- Overcomes imatinib resistance in CML cells.
- Inhibits MEK/ERK and AKT signaling in CML cells.
- Has good oral bioavailability and pharmacokinetics.
- Induces complete tumor regression in nude mice bearing lung cancer patient xenografts.
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