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Medchemexpress LLC SB-772077B (dihydrochloride) | 607373-46-6 | 99.33% | 415.28 | 25 MG
Supplier: Medchemexpress LLC 25MGHY108518
SB-772077B dihydrochloride is an orally active aminofuran-based Rho kinase (ROCK) inhibitor. It has IC50 values of 5.6 nM for ROCK1 and 6 nM for ROCK2, reduces inflammatory cytokines, relaxes aortic rings, and lowers blood pressure. It is used in inflammatory disease research.
- Reduces LPS-induced inflammatory cytokines (TNF-α and IL-6) in primary human macrophages.
- Induces dose-dependent relaxation of Phenylephrine-precontracted rat aortic rings (IC50 of 39 nM).
- Significantly reduces blood pressure in spontaneously hypertensive and deoxycorticosterone acetate-induced hypertensive rats.
- Abolishes Angiotensin II-induced actin stress fiber formation in human primary aortic smooth muscle cells at 3 μM.
- Intended for research use only.
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