Learn More
STEMCELL Technologies SB202190, Size: 10 mg

Supplier: STEMCELL Technologies 72632

SB202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively (Davies et al.; Jiang et al.). As a pyridinyl imidazole inhibitor, SB202190 directly binds p38 MAP kinases in the ATP binding pocket (Fox et al.).MAINTENANCE AND SELF-RENEWAL· Improves the self-renewal ability of neural stem cells from NPC1-deficient mice (Yang et al.).· Blocks adiponectin-mediated proliferation of hematopoietic stem cells (DiMascio et al.).· Reduces BMP3-mediated proliferation of C3H10T1/2 mesenchymal stem cells (Stewart et al.). DIFFERENTIATION· Induces cardiomyocyte differentiation from human embryonic stem cells (Graichen et al.).
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.