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Medchemexpress LLC SB225002 | 182498-32-4 | 99.9% | 352.14 | 50 MG
SDP

Catalog No. 502029212
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SB225002 is a potent, selective, and non-peptide CXCR2 antagonist. It inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. This compound demonstrates high selectivity over CXCR1 and other 7-TMRs, acting as a potent antagonist of rabbit CXCR2 and inhibiting calcium mobilization. It has also shown to decrease cell proliferation in certain cell lines and block IL-8-induced neutrophil margination in vivo.

  • Potent, selective, and non-peptide CXCR2 antagonist
  • Inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM
  • Shows >150-fold selectivity over CXCR1
  • Inhibits IL-8 and GROα-mediated calcium mobilization
  • Decreases cell proliferation in vitro
  • Blocks IL-8-induced neutrophil margination in vivo
  • Attenuates microglial activation and BBB damage in vivo

Catalog No. 50-202-9212 Supplier Medchemexpress LLC Supplier No. HY1671150MG
May include imposed supplier surcharges.
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SB225002 is a potent, selective, and non-peptide CXCR2 antagonist. It inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. This compound demonstrates high selectivity over CXCR1 and other 7-TMRs, acting as a potent antagonist of rabbit CXCR2 and inhibiting calcium mobilization. It has also shown to decrease cell proliferation in certain cell lines and block IL-8-induced neutrophil margination in vivo.

  • Potent, selective, and non-peptide CXCR2 antagonist
  • Inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM
  • Shows >150-fold selectivity over CXCR1
  • Inhibits IL-8 and GROα-mediated calcium mobilization
  • Decreases cell proliferation in vitro
  • Blocks IL-8-induced neutrophil margination in vivo
  • Attenuates microglial activation and BBB damage in vivo

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