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AdipoGen SB415286
Supplier: AdipoGen AGCR13658M001
Chemical. CAS 264218-23-7. Formula C16H10ClN3O5. MW 359.7. Synthetic. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM and similar potency for GSK3beta. DYRK1A inhibitor IC50=0.9µM. Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription. Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. Anticancer agent with antiproliferative activity. Glycogen synthase kinase 3 GSK3 is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation.
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