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Cell Signaling Technology Chemical Modulator, SB431542, Lyophilized, >98% Purity, 1 mg
SDP

Catalog No. 502050479
Encompass

SB431542 is a potent and selective ATP-competitive inhibitor of transforming growth factor β1 (TGF-β1) activin receptor-like kinases (ALK)-4, -5, and -7. It functions by inhibiting Smad2 signaling induced by TGF-β and activin without affecting BMP-induced Smad1 activation.

  • Inhibits ALK4 and ALK5 with IC50 values of 140 nM and 94 nM, respectively, with slightly less potency against ALK7.
  • Displays 100-fold greater selectivity for ALK5 compared to 25 other kinases, including p38 MAPK and JNK1.
  • Enhances the proliferation and integrity of ESC-derived endothelial cells.
  • Supplied as a lyophilized powder with >98% purity.
  • Reconstitute 1 mg in 260.15 μL DMSO for a 10 mM stock.

Catalog No. 50-205-0479 Supplier Cell Signaling Technology Supplier No. 14775S
May include imposed supplier surcharges.
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SB431542 is a potent and selective ATP-competitive inhibitor of transforming growth factor β1 (TGF-β1) activin receptor-like kinases (ALK)-4, -5, and -7. It functions by inhibiting Smad2 signaling induced by TGF-β and activin without affecting BMP-induced Smad1 activation.

  • Inhibits ALK4 and ALK5 with IC50 values of 140 nM and 94 nM, respectively, with slightly less potency against ALK7.
  • Displays 100-fold greater selectivity for ALK5 compared to 25 other kinases, including p38 MAPK and JNK1.
  • Enhances the proliferation and integrity of ESC-derived endothelial cells.
  • Supplied as a lyophilized powder with >98% purity.
  • Reconstitute 1 mg in 260.15 μL DMSO for a 10 mM stock.

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