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Apexbio Technology LLC SB590885 405554-55-4 250mg
Supplier: Apexbio Technology LLC B1406250
SB590885 is a small-molecule inhibitor targeting B-Raf kinase It is designed to inhibit B-Raf activity thereby regulating the MAPK signaling pathway SB590885 exerts its biological activity primarily through direct binding to the ATP-binding pocket of B-Raf stabilizing its active conformation In cellular models harboring the B-Raf V600E mutation SB590885 demonstrates preferential inhibition with a Ki value of 0 16 nM for oncogenic B-Raf and shows significantly lower affinity for C-Raf Based on these pharmacological properties SB590885 holds research potential in studying B-Raf-driven tumorigenesis and evaluating therapeutic strategies targeting aberrant MAPK signaling pathways
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