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Apexbio Technology LLC SB742457 607742-69-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B22565.1
SB742457 (CAS 607742-69-8) is a selective antagonist of the serotonin 5-HT6 receptor with high affinity demonstrated by a reported pKi of 9 63 Due to effective brain penetration and oral bioavailability SB742457 has shown the ability to reverse cognitive deficits induced by the cholinergic antagonist scopolamine in rodent novel object recognition tests Acutely administered SB742457 increases extracellular glutamate and acetylcholine levels in the rat medial prefrontal cortex Given these pharmacological properties SB742457 is investigated in cognitive enhancement studies notably related to Alzheimer s disease research
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