Apexbio Technology LLC SB743921 940929-33-9 200mg

Supplier:  Apexbio Technology LLC B1590200

SB743921 (CAS 940929-33-9) is a potent and selective inhibitor of kinesin spindle protein (KSP) exhibiting a Ki of 0 1 nM for human KSP and 0 12 nM for mouse KSP with negligible affinity for other kinesins By targeting KSP SB743921 disrupts mitotic spindle formation leading to cell cycle arrest and apoptosis In cellular assays SB743921 demonstrates strong antiproliferative activity against SKOV3 Colo205 MV522 and MX1 cell lines with IC50 values ranging from 0 02 to 1 7 nM Additionally it shows efficacy in multiple human tumor xenograft models and in a murine P388 lymphocytic leukemia model SB743921 is utilized in oncology research for mechanistic studies and therapeutic evaluation of mitotic inhibition

Catalog No. 50-000-92611