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Cayman Chemical SBE 13hydrochlorIde 50mg
SDP

Supplier:  Cayman Chemical 2124150 MG

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A positive allosteric modulator of mGluR5 (EC50s 0 17 and 0 23 M for potentiation of glutamate activity in HEK293 cells expressing rat mGluR5 and primary astrocyte cultures respectively) selective for mGluR5 over rat mGluR1 and human mGluR1 and mGluR4 at 10 M decreases the conditioned avoidance response apomorphine-induced climbing as well as PCP- apomorphine- and amphetamine-induced locomotor activity in rats in a dose-dependent manner improves recall in a novel object recognition test and reduces impulsivity in the 5CSRTT from 0 1-50 mg/kg enhances reversal learning in mice in the Morris water maze test

Catalog No. 50-298-5248


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