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Apexbio Technology LLC SBI-0206965 1884220-36-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A87155.1
SBI-0206965 (CAS 1884220-36-3) is a small-molecule inhibitor targeting ULK1 (UNC-51-like kinase 1) a serine/threonine kinase pivotal in regulating autophagy initiation ULK1 functions downstream of mTORC1 and is modulated by AMPK influencing cellular responses to nutrient deprivation In cellular assays using A549 cells SBI-0206965 at 5 mM effectively suppresses AZD8055-induced autophagy and increases apoptotic response upon nutrient starvation in MEFs U87MG glioblastoma and mouse lung cancer cell lines SBI-0206965 serves as a useful research tool for investigating autophagy pathways tumor cell survival and apoptosis mechanisms
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