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Medchemexpress LLC SBI-581 | 98.2% | 383.44 | 25 MG
Supplier: Medchemexpress LLC 25MGHY139439
SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor with an IC50 of 42 nM. It promotes TKS5α accumulation at RAB11-positive vesicles and inhibits invadopodia formation. The compound demonstrates reasonable pharmacokinetics in mice and shows antitumor activity. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Orally active and potent selective serine-threonine kinase TAO3 inhibitor
- Promotes TKS5α accumulation at RAB11-positive vesicles
- Inhibits invadopodia formation
- Demonstrates reasonable pharmacokinetics in mice
- Shows antitumor activity
- Click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition
- Moderate selectivity against a broad panel of kinases
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