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Cayman Chemical SC-560 asy Reagent 1ea
Supplier: Cayman Chemical 7601591 EA
A sesquiterpenoid with diverse biological activities selectively RXRB over RXRa and RXRY in reporter assays using HEK293T cells (EC50s 5.2 27 and 43 UM respectively) as well as RARs PPARs LXRs FXR CAR VDR and PXR at 30 UM enhances GABA-induced activation of a1B2Y2-subunit containing GABA receptors in CHO cells (EC50 12.6 UM) cytotoxic to GLC-4 and COLO 320 cells (IC50s 127 and 124 UM respectively) decreases motor performance in the rotarod test and increases pentobarbital-induced sleeping time in mice at 100 mg/kg i.p. increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice indicating anxiolytic-like activity at 12 mg/kg
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