Medchemexpress LLC SCD1 inhibitor-1 | 1069094-65-0 | 99.9% | 451.54 | 10 MG

Supplier:  Medchemexpress LLC HY11281210MG

SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity.

• Orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1).
• IC50 of 8.8 nM for recombinant human SCD1 enzyme.
• Improved effect in high-fat mice models (3-10 mg/kg; oral administration; 43 days), showing improved glucose tolerance in a dose-dependent manner and decreased body weight.
• Improved effect in high-sucrose rat models (1-10 mg/kg; oral administration; single dose), inhibiting SCD1 inhibitory activity in a dose-dependent manner in epididymal adipose tissue and the liver 6 hours after oral administration.
• Selective tissue distribution of liver/eyelid.

Catalog No. 50-004-36365