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Medchemexpress LLC SCD1 inhibitor-1 | 1069094-65-0 | 99.91% | 451.54 | 50 MG
Supplier: Medchemexpress LLC HY11281250MG
SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. It can be utilized in the study of various conditions such as diabetes, hepatic steatosis, and obesity.
- Orally active.
- Liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1).
- Exhibits an IC50 of 8.8 nM for recombinant human SCD1 enzyme.
- Applicable in the study of diseases including diabetes, hepatic steatosis, and obesity.
- Improved glucose tolerance in a dose-dependent manner in high-fat mice models.
- Decreased body weight in a mild dose-dependent manner in high-fat mice models.
- Inhibited SCD1 inhibitory activity in a dose-dependent manner in epididymal adipose tissue and the liver of high-sucrose rat models.
- Shows selective tissue distribution, specifically in the liver/eyelid.
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