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Medchemexpress LLC SCH772984 | 942183-80-4 | 99.8% | C33H33N9O2 | 200 MG
Supplier: Medchemexpress LLC HY50846200MG
SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 nM for ERK1 and 1 nM for ERK2. It exhibits antitumor activity in both MAPK inhibitor-naive and MAPK inhibitor-resistant cells that contain BRAF or RAS mutations.
- Highly selective and ATP-competitive ERK inhibitor
- Exhibits antitumor activity in MAPK inhibitor-naive and resistant cells
- Induces G1 arrest and apoptosis in sensitive melanoma cells
- Inhibits ERK and RSK phosphorylation
- Shows EC50 values less than 500 nM in BRAF-mutant and RAS-mutant tumor lines
- Leads to significant tumor regression in animal models
- Well tolerated in vivo
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