Apexbio Technology LLC SCH772984 HCl 942183-80-4 (free base) 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B58665.1

SCH772984 HCl is a selective inhibitor targeting extracellular signal-regulated kinases 1 and 2 (ERK1/2) members of the mitogen-activated protein kinase (MAPK) pathway ERK activation is commonly implicated in cancer proliferation particularly in tumors harboring BRAF or RAS mutations SCH772984 HCl binds specifically to ERK1/2 blocking their kinase activity and downstream substrate phosphorylation In cell-based experiments it inhibits phosphorylation of ERK substrates such as p90 ribosomal S6 kinase (RSK) and decreases phosphorylation of ERK1/2 activation-loop residues In vivo SCH772984 HCl reduces tumor growth in xenograft mouse models bearing human melanoma cells with BRAF V600E mutation This compound is widely used in cancer research to study ERK-mediated signaling pathways and models exhibiting resistance to BRAF and MEK inhibitor therapies

Catalog No. 50-000-63565