Apexbio Technology LLC SCH900776 S-isomer 891494-64-7 20mg

Supplier:  Apexbio Technology LLC A380620

SCH900776 S-isomer is a small-molecule inhibitor targeting checkpoint kinase 1 (Chk1) It is designed to inhibit Chk1 kinase activity thereby interfering with DNA damage-induced checkpoint responses and disrupting S-phase cell-cycle arrest SCH900776 S-isomer exerts its biological activity primarily through selective inhibition of Chk1 kinase (IC50 3 nM) with substantially weaker inhibition toward Chk2 (IC50 1500 nM) and CDK2 (IC50 160 nM) In cellular assays treatment with SCH900776 S-isomer mimics the genetic depletion of CHK1 by RNA interference Based on these pharmacological properties SCH900776 S-isomer holds research potential in oncology particularly in combination with DNA-damaging chemotherapeutics to study enhanced cytotoxicity and altered cell-cycle progression in tumor and leukemia cell lines

Catalog No. 50-000-96830