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Cayman Chemical SchIsndrol B 10mg
Supplier: Cayman Chemical 2514910 MG
A lignan with hepatoprotective activity; increases the expression of the PXR target genes Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells; protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice; decreases mortality in a mouse model of cholestasis at 100 mg/kg twice per day
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