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Apexbio Technology LLC SCR7 1533426-72-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A87055.1
SCR7 (CAS 1533426-72-0) is a small-molecule inhibitor targeting DNA ligase IV and to a lesser extent DNA ligase III It interacts with the DNA-binding domain of DNA ligase IV thereby diminishing its affinity for double-strand breaks (DSBs) and effectively blocking nonhomologous end-joining (NHEJ)-mediated DNA repair In cell culture models expressing inducible Cas9 SCR7-mediated transient inhibition of NHEJ promotes increased homologous-directed repair (HDR) by facilitating accumulation in the S/G2 phase SCR7 treatment in mice transiently impairs lymphocyte development due to the reversible inhibition of DNA ligase IV activity during V(D)J recombination Thus SCR7 serves as a useful tool in genome editing research to enhance precise gene editing efficiency
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