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Apexbio Technology LLC SCR7 pyrazine 14892-97-8 25mg
Supplier: Apexbio Technology LLC C494125
SCR7 pyrazine (CAS 14892-97-8) is a small-molecule inhibitor of DNA ligase IV a critical enzyme in the nonhomologous end-joining (NHEJ) pathway responsible for repairing DNA double-strand breaks (DSBs) By disrupting the DNA binding activity of ligase IV SCR7 impedes the NHEJ-mediated repair process leading to reduced cell viability and increased apoptosis In cellular assays SCR7 demonstrated dose-dependent inhibition of proliferation in various cancer cell lines with reported IC50 values ranging from 8 5 to 120 M Additionally in mouse models SCR7 administration suppressed tumor growth and enhanced sensitivity to DSB-inducing therapies highlighting its utility for studying DNA repair mechanisms and potential as an adjunct in cancer research
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