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Apexbio Technology LLC SEA0400 223104-29-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A38115.1
SEA0400 (CAS 223104-29-8) is a selective inhibitor of the sodium-calcium exchanger (NCX) an antiporter responsible for cellular calcium homeostasis by facilitating sodium-calcium ion exchange across membranes SEA0400 inhibits NCX activity at nanomolar concentrations (IC50 between 5-33 nM in neuronal and glial cell cultures) with substantially higher potency than KB-R7943 By blocking reverse-mode NCX function during reperfusion scenarios SEA0400 reduces pathological intracellular calcium influx and downstream pro-inflammatory mediator production It has demonstrated neuroprotective effects by reducing infarction volumes in rodent cerebral ischemia models as well as anti-arrhythmic properties in myocardial infarction models
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