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Medchemexpress LLC Sec61-IN-1 (compound A317) | 2484865-42-9 | 99.7% | C23H22N6OS | 10MG
Supplier: Medchemexpress LLC HY13961510MG
Sec61-IN-1 (compound A317) is a small-molecule inhibitor of the Sec61 translocon developed for research use. It selectively inhibits Sec61-mediated protein translocation, shows cytotoxic activity in certain glioma models, and can enhance T cell-mediated cytotoxicity in vitro; it also shows measurable brain exposure in mouse studies. Supplied as a solid or as a DMSO solution for laboratory studies.
- Potent Sec61 inhibition in vitro.
- Enhances T cell-mediated cytotoxicity against glioma cells.
- Demonstrated activity in SEC61G-EGFR amplified glioblastoma models.
- Detectable brain exposure after intravenous dosing in mice.
- Available as solid and as a DMSO solution for formulation flexibility.
- High purity suitable for research (99.7%).
- Recommended storage conditions provided to preserve stability.
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