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Cayman Chemical Secretase Inhibitor IV 5mg
Supplier: Cayman Chemical 233885 MG
An inhibitor of BACE1 and 2 (IC50s = 15 and 230 nM for human BACE1 and 2, respectively); has >500-fold selectivity for BACE1 and 2 over the aspartyl proteases renin and cathepsin D; inhibits secretion of APP (IC50 = 29 nM) in HEK293T cells transfected with a truncated human APP; inhibits formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively)
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